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Joel Zylberberg Laboratory

Computational Neuroscience and Machine Learning

Advancing our understanding of brain function and vision with machine learning and computational models

Dr. Joel Zylberberg

Joel Zylberberg, Ph.D.

Associate Professor

  • Department of Ophthalmology
  • Jules Stein Eye Institute

Dr. Joel Zylberberg is a computational neuroscientist whose work bridges neuroscience and machine learning. His research focuses on understanding how the brain processes information about the world and how those representations are learned. By combining computational modeling with experimental data, Dr. Zylberberg aims to develop bio-inspired machine learning algorithms and improve our understanding of sensory systems like the retina and visual cortex.

Key research questions include:

  • How does the brain encode and process sensory information?
  • What are the neural mechanisms underlying robust information propagation in noisy circuits?
  • How can bio-inspired algorithms improve artificial intelligence systems?
  • What are the roles of synaptic plasticity in shaping neural representations?
  • How can computational models of vision aid in developing retinal prosthetics?

Dr. Zylberberg's lab employs cutting-edge techniques in computational neuroscience, including deep learning frameworks and information theory, to uncover the principles of brain function and apply them to real-world problems in AI and medicine.

Membrane receptor research diagrams showing protein structures, molecular pathways, and experimental results

Lab Members

Recent Publications

Designing stimuli for non-invasive, cell-type-specific manipulation of retinal ganglion cell activity

Niloufar Ghazavi, Saad Idrees, Vyom Manish Raval, Michael B. Manookin, Fred Rieke, Greg D. Field, Joel Zylberberg

2026

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Fine Granularity Is Critical for Intelligent Neural Network Pruning

Alex Heyman, Joel Zylberberg

Neural Computation (2024)

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Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation

Saad Idrees, Michael B. Manookin, Fred Rieke, Greg D. Field, Joel Zylberberg

Nature Communications (2024)

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Stimulus type shapes the topology of cellular functional networks in mouse visual cortex

Disheng Tang, Joel Zylberberg, Xiaoxuan Jia, Hannah Choi

Nature Communications (2024)

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Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites

Colleen J. Gillon, Jason E. Pina, Jérôme A. Lecoq, Ruweida Ahmed, Yazan N. Billeh, Shiella Caldejon, …, Joel Zylberberg, et al.

The Journal of Neuroscience (2024)

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Towards automated sleep-stage classification for adaptive deep brain stimulation targeting sleep in patients with Parkinson’s disease

Katrina Carver, Karin Saltoun, Elijah Christensen, Aviva Abosch, Joel Zylberberg, John A. Thompson

Communications Engineering (2023)

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Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days

Colleen J. Gillon, Jérôme A. Lecoq, Jason E. Pina, Ruweida Ahmed, Yazan N. Billeh, Shiella Caldejon, …, Joel Zylberberg, et al.

Scientific Data (2023)

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Good decisions require more than information

N. Alex Cayco-Gajic, Joel Zylberberg

Nature Neuroscience (2021)

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Cellular and Synaptic Mechanisms That Differentiate Mitral Cells and Superficial Tufted Cells Into Parallel Output Channels in the Olfactory Bulb

Shelly Jones, Joel Zylberberg, Nathan Schoppa

Frontiers in Cellular Neuroscience (2020)

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Improved object recognition using neural networks trained to mimic the brain’s statistical properties

Callie Federer, Haoyan Xu, Alona Fyshe, Joel Zylberberg

Neural Networks (2020)

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